Mashpee is a town in Barnstable County, Massachusetts, United States, on Cape Cod. The population was 14,006 as of 2010. It is the site of the headquarters and most members of the federally recognized Mashpee Wampanoag Tribe, one of two Wampanoag.For geographic and demographic information on specific parts of the town of Mashpee, please see the articles on Mashpee Neck, Monomoscoy Island, New Seabury, Popponesset, Popponesset Island, Seabrook, and Seconsett Island.